In some ways, the inauguration will be much the same as previous ones – Mr Biden will take the oath of office on the steps of the Capitol and then make his way to the White House.
But with the event happening just two weeks after supporters of President Donald Trump stormed the Capitol – and coming amid a global pandemic – there will be lots of differences.
Here’s a look at what measures have been put into place to deal with heightened concerns about security and Covid-19: